The Veterans Affairs Central Cancer Registry (VACCR) receives and stores information on cancer diagnosis and treatment constraints compiled and sent in by the local cancer registry staff at each of the 132 Veterans Affairs Medical Centers that diagnose and/or treat Veterans with cancer. The information sent is encoded to meet the site-specific requirements for registry inclusion as established by several oversight bodies, including the North American Association of Central Cancer Registries, the American College of Surgeons' Commission on Cancer, and the American Joint Commission on Cancer, among others. The information is obtained from a wide variety of medical record documents at the local medical center pertaining to each Veterans Health Administration (VHA) cancer patient. The information is then transmitted to the VACCR. Details collected include extensive demographics, cancer identification, extent of disease and staging, first course of treatment, and outcomes. Data extraction is available to researchers with VA approved Institutional Review Board studies, peer review, and Data Use Agreements.

The Spinal Cord Dysfunction (SCD) module supports the maintenance of local and national registries for the tracking of patients with spinal cord injury and disease from both traumatic and non-traumatic causes. SCD includes features for clinical, management, and research staff. Clinicians benefit from the ability to see profiles of SCD patients, ensure that regular annual exams are completed, and measure patient outcomes. Managers have a suite of reports that reflect the resources needed to care for SCD patients. Researchers have access to a national registry for all Veteran SCD patients and their associated health care events.

The Emerging Pathogens Initiative (EPI) database contains emerging pathogens information from the local Veterans Affairs Medical Centers (VAMCs). The EPI software package allows the VA to track emerging pathogens on the national level without additional data entry at the local level. The results from aggregation of data can be shared with the appropriate public health authorities including non-VA and the private health care sector allowing national planning, formulation of intervention strategies, and resource allocations. EPI is designed to automatically collect data on emerging diseases for Veterans Affairs Central Office (VACO) to analyze. The data is sent to the Austin Information Technology Center (AITC) from all Veterans Health Information Systems and Technology Architecture (VistA) systems for initial processing and combination with related workload data. VACO data retrieval and analysis is then carried out. The AITC creates two file structures both in Statistical Analysis Software (SAS) file format, which are used as a source of data for the Veterans Affairs Headquarters (VAHQ) Infectious Diseases Program Office. These files are manipulated and used for analysis and reporting by the National Infectious Diseases Service. Emerging Pathogens (as characterized by VACO) act as triggers for data acquisition activities in the automated program. The system retrieves relevant, predetermined, patient-specific information in the form of a Health Level Seven (HL7) message that is transmitted to the central data repository at the AITC. Once at that location, the data is converted to a SAS dataset for analysis by the VACO National Infectious Diseases Service. Before data transmission an Emerging Pathogens Verification Report is produced for the local sites to review, verify, and make corrections as needed. After data transmission to the AITC it is added to the EPI database.